A new study from the National Institute on Drug Abuse and the Beijing Institute of Pharmacology and Toxicology learned that the appeal of cocaine can be significantly reduced by activating a specific kind of receptor in the brain. The researchers trained mice to give themselves cocaine, then gave the animals a compound called JWH133, which shuts off a cannibinoid receptor in the brain called CB2. Some mice responded by giving themselves less of the drug. The researchers learned that the more JWH133 the mice received, the lower their desire was for the cocaine. The researchers believe this was because the cocaine did not make them feel the “high” anymore from the cocaine.